2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W142506
    Triethylene glycol monododecyl ether 3055-94-5 99.98%
    Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Triethylene glycol monododecyl ether
  • HY-W096152
    Chloroacetamido-C4-NHBoc 133264-58-1
    Chloroacetamido-C4-NHBoc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Chloroacetamido-C4-NHBoc
  • HY-140633
    Ald-C2-PEG4-azide 2030118-14-8
    Ald-C2-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Ald-C2-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ald-C2-PEG4-azide
  • HY-140396C
    Aminooxy-PEG3-bromide hydrobromide ≥98.0%
    Aminooxy-PEG3-bromide hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG3-bromide hydrobromide
  • HY-140250A
    Tri(Amino-PEG4-amide)-amine TFA
    Tri(Amino-PEG4-amide)-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tri(Amino-PEG4-amide)-amine TFA
  • HY-141225
    m-PEG24-alcohol 2376450-73-4
    m-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-alcohol
  • HY-140180
    Amino-PEG20-acid
    Amino-PEG20-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG20-acid
  • HY-138415
    Azido-PEG11-CH2COOH 2567584-97-6
    Azido-PEG11-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG11-CH2COOH
  • HY-140993
    Bis-Mal-PEG3 1008402-47-8
    Bis-Mal-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-Mal-PEG3
  • HY-169992
    1-Bromo-4-(ethynyloxy)butane
    1-Bromo-4-(ethynyloxy)butane is the PROTAC linker of ACBI3 (HY-157228) and can be used in the synthesis of PROTACs.
    1-Bromo-4-(ethynyloxy)butane
  • HY-140042
    Bis-propargyl-O-PEG17
    Bis-propargyl-O-PEG17 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-propargyl-O-PEG17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-O-PEG17
  • HY-138478
    THP-PEG13-Boc
    THP-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG13-Boc
  • HY-140040
    Bis-propargyl-PEG12 1351373-50-6
    Bis-propargyl-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-propargyl-PEG12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG12
  • HY-140860
    Trityl-PEG8-azide 1818294-30-2
    Trityl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Trityl-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Trityl-PEG8-azide
  • HY-140486
    Acid-PEG6-mono-methyl ester 1807512-38-4
    Acid-PEG6-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG6-mono-methyl ester
  • HY-140074
    endo-BCN-PEG4-Boc 1807501-83-2
    endo-BCN-PEG4-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    endo-BCN-PEG4-Boc
  • HY-138471
    Azido-PEG2-C6-OH
    Azido-PEG2-C6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C6-OH
  • HY-141311
    m-PEG4-phosphonic acid ethyl ester 1872433-73-2
    m-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-phosphonic acid ethyl ester
  • HY-140912
    Biotin-PEG11-azide 2276672-04-7
    Biotin-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG11-azide
  • HY-138330
    Fmoc-PEG5-NHBoc
    Fmoc-PEG5-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG5-NHBoc
PROTAC Linkers Isoform Comparison

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